Production of biogas from cow dung and brewer’s spent grain was investigated using the anaerobic digestion in 50litre digester. The experiment was batch operated and daily gas yield from the plant was monitored for 30 days. The ambient and slurry temperature, pH, and Pressure were also monitored and presented. The slurry was characterized before charging with the American Public Health Association standard. The digester was charged differently with these wastes in the ratio of 1:2 of waste to water respectively. The mesophilic ambient temperatures range attained within the testing period were 20 – 32 ^oC and a slurry temperature range of 22–36 ^oC. The biogas produced was analyzed with digital gas analyzer. The result obtained from the gas production showed that cow dung produced the highest methane content of 58% while brewer’s spent grain has the least methane content of 20%. During the digestion period, the volume of biogas production and the changes in pH indicate that at neutral pH, the highest peak of gas production was attained and that at slightly acidic pH range, there was no gas production. These results showed that these wastes could be a source of renewable gas if managed properly since each of the waste sluggishly continued gas production after the 30 days retention time.